An Extensive Review on Production, Purification, and Bioactive Application of Different Classes of Bacteriocin

Lactic Acid Bacteria (LAB) synthesize various metabolites during their growth phase and are Generally Recognized as­­ Safe (GRAS) Qualified Presumption of Safety (QPS). Ribosomally synthesized Antimicrobial Peptides (AMP) or Bacteriocins from the genera other prokaryotic cationic, heat-stable, amphiphilic membrane permeabilizing peptides built with an excess amount lysyl arginyl residues. compounds produced by LAB depend on physical biological conditions microbial culture. Different classes bacteriocin both Gram-positive Gram-negative bacteria. The production is influenced environmental factors. Bacteriocin has a wide variety applications in fields. application spectrum bacteriocins can be expanded domains such as food processing, biomedical, personal care due to increase number newly discovered bacteriocins. acquire antimicrobial activity minimal level cytotoxicity. In addition, were studied for anticancer against different cancer cell lines. Selective binding (cationic) towards cells (anionic) increases cytotoxicity cells. initiate necrosis communicating surface which selectively targets kills tumor formation does not cause any damage normal healthy this review, lactic acid bacteria along interaction lines discussed few examples bioactive LAB.